MRI Research Amsterdam UMC


AUMC PROUD is an MRI scanner software patch enabling
PROspective Undersampling in Multiple Dimensions on a cartesian k-space grid.

This combines the flexibility of performing accelerated / undersampled acquisitions with the robustness of cartesian k-space trajectories. The AUMC PROUD patch is available for Philips MR systems running on R5.4.1 or higher. Instead of hard coded trajectories, the patch loads the trajectory from an input file which can be stored locally and attached permanently to specific MR protocols for clinical research purposes.

The AUMC PROUD patch is compatible with 2D and 3D TFE & TSE cartesian k-space sequences, and has advanced functionalities for retrospectively gated cardiac sequences (e.g. 4D Flow).
The patch is compatible with off-line reconstruction in Philips Recon 2.0 or MRecon (Gyrotools).

Current team
Bram Coolen, PhD
Matthan Caan, PhD
Eric Schrauben, PhD
Erik Akkerman, PhD
Bobby Runderkamp, MSc (7T)
Lukas Gottwald, PhD (Philips)
Pim van Ooij, PhD

Former developers
Eva Peper, PhD
Wouter Potters, PhD
Qinwei Zhang, PhD
Maarten Versluis, PhD (Philips)

This software is for research purposes only and not meant for clinical use. The software will only be shared with sites who have a research agreement with Philips for the use of software patches.
For collaborations concerning use of the AUMC PROUD patch, please email:
Use of the PROUD patch will be subject to our ‘Terms of Agreement‘.

Publications using PROUD

Merton R, Bosshardt D, Strijkers GJ, Nederveen AJ, Schrauben EM, van Ooij P. “Reproducibility of 3D thoracic aortic displacement from 3D cine balanced SSFP at 3 T without contrast enhancement“; Magn Reson Med 2024

van Schelt A-S, Gottwald LM, Wassenaar NPM, Runge JH, Sinkus R, Stoker J, Nederveen AJ, Schrauben EM. “Single Breath‐Hold MR Elastography for Fast Biomechanical Probing of Pancreatic Stiffness”; J Magn Reson Imaging 2023; 59(2): 688-698;

van Andel MM, van Ooij P, de Waard V, Gottwald LM, van Kimmenade RRJ, Scholte AJ, Zwinderman AH, Mulder BJM, Nederveen AJ, Groenink M. “Abnormal aortic hemodynamics are associated with risk factors for aortic complications in patients with marfan syndrome“; Int J Cardiol Heart Vasc 2022; 17(43): 101128

Blanken CPS, Schrauben EM, Peper ES, Gottwald LM, Coolen BF, van Wijk DF, Piek JJ, Strijkers GJ, Planken RN, van Ooij P, Nederveen AJ. “Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction”; Front Bioeng Biotechnol 2021; 9: 725833
Blanken CPS, Gottwald LM, Westenberg J, Peper ES, Coolen BF, Strijkers GJ, Nederveen AJ, Planken RN, van Ooij P. “Whole‐Heart 4D Flow MRI for Evaluation of Normal and Regurgitant Valvular Flow: A Quantitative Comparison Between Pseudo‐Spiral Sampling and EPI Readout”; J Magn Reson Imaging 2021; DOI: 10.1002/jmri.27905
Gottwald LM, Blanken CPS, Tourais J, Smink J, Planken RN, Boekholdt SM, Meijboom LJ, Coolen BF, Strijkers GJ, Nederveen AJ, van Ooij P. “Retrospective Camera-Based Respiratory Gating in Clinical Whole-Heart 4D Flow MRI”; J Magn Reson Imaging 2021; 54: 440-451

Gottwald LM, Töger J, Markenroth Bloch K, Peper ES, Coolen BF, Strijkers GJ, van Ooij P, Nederveen AJ.
High Spatiotemporal Resolution 4D Flow MRI of Intracranial Aneurysms at 7T in 10 Minutes”; Am J Neuroradiol 2020; 41: 1201-1208
Schoormans J, Strijkers GJ, Hansen AC, Nederveen AJ, Coolen BF. “Compressed sensing MRI with variable density averaging (CS-VDA) outperforms full sampling at low SNR” ;Phys Med Biol 2020; 65: 045004
Peper ES, Gottwald LM, Zhang Q, Coolen BF, van Ooij P, Nederveen AJ, Strijkers GJ
Highly accelerated 4D flow cardiovascular magnetic resonance using a pseudo-spiral Cartesian acquisition and compressed sensing reconstruction for carotid flow and wall shear stress”; J Cardiovasc Magn Reson 2020; 22: 7
Gottwald LM, Peper ES, Zhang Q, Coolen BF, Strijkers GJ, Nederveen AJ, van Ooij P. “Pseudo-spiral sampling and compressed sensing reconstruction provides flexibility of temporal resolution in accelerated aortic 4D flow MRI: A comparison with k-t principal component analysis” ; NMR Biomed 2020; e4255

de Jonge CS, Coolen BF, Peper ES, Motaal AG, Nio CY, Somers I, Sijkers GJ, Stoker J, Nederveen AJ. “Evaluation of compressed sensing MRI for accelerated bowel motility imaging”; Eur Radiol Exp 2019; 3: 7
Lønning, K., Putzky, P., Sonke, J.-J., Reneman, L., Caan, M.W.A., Welling, M. “Recurrent inference machines for reconstructing heterogeneous MRI data”; Med Image Anal 2019; 53: 64–78.

Mazzoli V, Gottwald LM, Peper ES, Froeling M, Coolen BF, Verdonschot N, Sprengers AM, van Ooij P, Strijkers GJ, Nederveen AJ. “Accelerated 4D phase contrast MRI in skeletal muscle contraction”; Magn Reson Med 2018; 80 (5): 1799-1811
Peper ES, Strijkers GJ, Gazzola K, Potters WV, Motaal AG, Luirink IK, Hutten BA, Wiegman A, van Ooij P, van den Born BH, Nederveen AJ, Coolen BF. “Regional assessment of carotid artery pulse wave velocity using compressed sensing accelerated high temporal resolution 2D CINE PC MRI“; J Cardiovasc Magn R 2018; 20: 86

Research team