The Preclinical MRI lab is hosted by the Biomedical Engineering & Physics department and led by prof. Gustav Strijkers and dr. Bram Coolen. It is equipped with a state-of-the-art 7T small animal cryogen free MR system (MR Solutions, Gilford, UK). MRI enables non-invasive, high-resolution anatomical imaging up to 50 mm with excellent soft-tissue contrast and unlimited penetration depth. It is therefore suitable to longitudinally study a large range of animal models in the fields of oncology, cardiology, neurology and regenerative medicine. MRI not only sensitively detects various pathological changes in tissue structure, such as edema, fibrosis, calcification, etc. but also enables characterization of a variety of physiological measures, such as diffusion, perfusion, flow and motion (e.g. cardiac function). Finally, the use of targeted or non-targeted MRI contrast agents might increase sensitivity to specific disease processes, e.g. inflammation or cell death following cerebral/myocardial infarction. Preclinical MRI has endless opportunities for studying different aspects of disease models and we encourage researchers to discuss these possibilities with our group.
More info on preclinical imaging @ Amsterdam UMC can be found here: https://www.amsterdamumc.org/en/research/core-facility/imaging-center/techniques/preclinical-imaging-.htm