MRI Research Amsterdam UMC

Cardiovascular MRI

Diseases of the cardiovascular system have a high morbidity and mortality. In our research group we investigate these diseases with cutting edge MRI technology for facilitated diagnosis, intervention and monitoring. We have a focus on several aspects of cardiovascular MRI across the lifespan from the fetus to the elderly.

4D flow MRI

4D flow MRI (three-dimensional and time-resolved phase contrast MRI) is a technique to measure blood flow velocity vectors in a volume of interest over a multitude of phases over the cardiac cycle. The rich data allows quantification of several hemodynamic parameters such as wall shear stress and pulse wave velocity. In the MRI Research Amsterdam UMC group we have developed accelerated 4D flow MRI based on pseudo-spiral undersampling combined with compressed sensing reconstruction, and have used 4D flow MRI to:

  • investigate flow patterns and wall shear stress in intracranial aneurysms
  • investigate the relation between wall shear stress and wall thickness in the atherosclerotic carotid bifurcation
  • investigate abnormal flow patterns in patients with bicuspid aortic valve disease and repaired aortic coarctation
  • quantify regurgitant flow in the heart in congenital heart disease
  • investigate reproducibility of 4D flow MRI in abdominal aortic aneurysms
Quantify regurgitant flow in the heart in congenital heart disease

3D Cine

Balanced steady-state free precession is the workhorse of cardiac MRI but acquired in 2D slices that do not allow retrospective angulation of planes for further analysis. For this reason we designed a 3D cine sequence that we use for:

  • quantification of aortic motion over the cardiac cycle in healthy volunteers and patients with Marfan syndrome
  • Real-time tracking of a catheter for cardiac ablation intervention
Quantification of aortic motion over the cardiac cycle using 3D cine in a healthy volunteer