The EU-funded NICI project will introduce an innovative approach to studying human biology using non-invasive chemistry imaging (NICI). Developing magnetic resonance imaging (MRI) to detect recently discovered metabolic biomarkers will enable the dynamic mapping of biochemical processes in the whole body. The project will develop a new methodology using co-cultured 3D organoids as models for human organs. It will develop a platform integrating 7T MRI scanners and associated data acquisition approaches to create a 3D biochemical imaging system. The dynamic 3D chemical imaging approach and its predictive and prognostic value will be validated in the stratification strategy for patients with liver metastasis of gastrointestinal cancer.